Yes. One of these, plus something like a small 2 channel Class D digital amp, like one from Arylic or Fosi Audio. Plenty of options to choose from, including some with Bluetooth onboard, or a third channel for a subwoofer. Run speaker cables to an innocuous spot, connect, and fire it up. I have done dozens of installs where the speaker cables meet up with the amp on a bookshelf, etc. I have even used hollowed-out books or other decorative items to hide them in plain sight.
I am holding out hope that someone like Arylic will add AirPlay 2 to their amp lineup, making it a one-unit plug-and-play add-on. Their existing stuff works very well as a distributed audio system, much like AirPlay 2, but has a few limitations (such as inability to stream from Apple Music or Sirius/XM).
If you want to run the speaker cables (or already have them run) to a central location, grab one of these for each zone you want to power, and use a multi-channel distributed home audio amplifier that has an input for each channel, and you are all set. Power the adapters off one of the myriad multi-output USB power bricks available for $30 everywhere. There aren't many multi-zone amps with individual inputs for each zone, and they aren't cheap, so using a multi-amp setup like described above is often a better solution.
Now, if a company like AudioSource would build in this type of capability to one of their existing multi-zone amps...