I'm a Camino user and I like a lot about it: the look, ad-blocking, double-click in tab bar to open a new tab, speed, and the (admittedly few) plug-ins.
Having said that, there's only one reason I don't use Safari instead, and that's becuase of the insanely annoying (to me, at least) toggle for stop/reload. You know how Flash is really crap on Macs and chokes up the processor, especially on older Macs? Or when you decide you don't want to wait for a image-heavy page to load? What do you do? You press the Stop button.
If the browswer is having a bad day and not responding, you tend to hit the Stop button again. And again. And again.
Then, when the browswer is back on its feet, with Safari it tries to Stop, then Reload, then Stop, then Reload etc. Of course, each time it tries to reload, the whole thing bogs down again.
If there's an option to have separate Stop and Reload buttons in Safari...I'll be back like a flash ('scuse the pun).