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California - Los Angeles County just issued an alert for 2nd dose Pfizer recipients.

Due to the lack of available vaccines, only 2nd dose recipients that are 65+ or HCW are allowed this week.
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My wife got her second dose(Pfizer) last week.

She took ibuprofen before and for a day after. It swelled up to a heck of a knot on her shoulder, more so than the first one, but no fever or other issues sometimes reported.

She has been rediculously tired the last couple days since getting it, and she's wondering if it's from the shot. Still, though, she was happy to get it and I'll certainly be rolling up my sleeve when my turn comes.

What blood types get more reactions to the vaccine ???

This is the first I'm hearing of this also.

There is at least one study that showed a link in blood type and COVID severity (https://www.hematology.org/newsroom...possible-link-between-blood-type-and-covid-19 , wish I could locate the source journal article) and more recent ones that have contradicted that(https://www.healio.com/news/hematol...on-blood-group-and-covid19-severity-mortality) .

I checked some academic databases and couldn't find anything published on a reported relationship between blood type and vaccine reaction. IF the blood type/severity link exists, I could believe it, but everything I've read points to that relationship being tenous at best and likely not existent.
 
Well I can’t get an appointment for my second shot. Only places available are 45 minutes away and nothing available when I could do it. Guess I’m not getting my second shot.
This has been disappointing. Got my 1st local and now they say drive to the other side of the state. Pass thanks
 
My wife got her second dose(Pfizer) last week.

She took ibuprofen before and for a day after. It swelled up to a heck of a knot on her shoulder, more so than the first one, but no fever or other issues sometimes reported.

She has been rediculously tired the last couple days since getting it, and she's wondering if it's from the shot. Still, though, she was happy to get it and I'll certainly be rolling up my sleeve when my turn comes.......
Recent warnings by the medical community says not to use ibuprofen before and after vaccines as they tend to suppress the immune response to create antibodies.

Instead, they recommend you allow the fever to occur and if needed for some relieve, acetaminophen can be used.
 
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Had my first shot 1/28, scheduled for mu second on 2/18. Appointments made through John Muir Health web site after getting an email saying appointments for 75+ were being scheduled.
Everything went smoothly, no waiting, in fact they took me 15 minutes before my scheduled time.
Waited 15 minutes then sent me on my way. No pain, no reaction. Very professional operation.
I live in the East Bay of the San Francisco area.
 
2nd dose update:

Pfizer vaccine #2 - LA County drive-thru vaccination - 24 hours later: site injection pain more than 1st dose, swollen lymph nodes, and achy muscles.

Surprised me - no other serious side effects!
 
My mom is at two days past dose #2 of Moderna. Had a fever of 99 at one point and has felt tired with a sore arm but otherwise good to go. I'm hoping I eventually fare the same!
 
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Finally got my email from the county health department here providing the link where I could go to schedule my second dose of Moderna, but unfortunately by the time I got into the site to look, no time slots available this next week (I could only have done Thursday or Friday anyway, since Thursday marks the 28th day since my first injection) so I'll have to keep trying..... Thankfully there is a good window of time within which one can get that second jab, so I'm not especially worried at this point.
 
I had the Oxford-AstraZeneca vaccine on Thursday just past. In my 40s but in the vulnerable group.

Sore arm, which is much better today. Had chills for about a day and quite tired for a couple. Felt a little rough but nothing major.
 
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My dad got his two doses. He said he felt fine after both. Still waiting to be eligible for mine.
 
I got my second Moderna 2 days ago and just now am starting to feel mostly right. Yesterday was pretty rough. Still WAY worth it though!!! Yesterday felt like a bad head cold with dizziness, fever, and body aches.
 
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I got my First shot of Pfizer on Thursday, I have an appointment for the 2nd one on March 4th. My wife got hers a week ago Saturday, and gets her 2nd one in 2 weeks. Her arm bothered her a little, mine was fine. I am pushing my people at work to get the shots, one of my engineers 12 year old daughter had a stroke while on the ventilator due to Covid, yet I still had to send someone home today who was tired of wearing his mask, it was just a conspiracy, I was so mad at him, I didnt even ask what the conspiracy was about. He's home on vacation or LWOP for the rest of the week. Hopefully for his families sake he comes back with a better attitude.
-Tig
 
Moderna vaccinations here. (Both completed.) No issues.

My wife is a cardiologist and had her second vaccination last week, no issues. We’re both in our mid 30’s.

[Anecdotally, I have to agree with an infectious disease doctor that she works with, and said that some reactions are worse depending on which blood type you are.]

Really ?

What blood types get more reactions to the vaccine ???

There was a very early study that suggested COVID-19 was more severe in people with Type A Blood. There have been several, much better studies since that have indicate there is no association between blood type and infection studies. I feel like trying to make associations between blood type and other factors is a bit trendy right now in popular culture. A lot of these studies are low quality though. Additionally, in many cases there is no logical hypothesis to connect blood type with a health metric or factor (i.e. risk of developing a disease), which may mean such observations are nothing more statistical correlations than actual causal relationships. So just be aware of that.

It's unlikely there is any difference between blood types and the COVID vaccine, albeit that's not something conventionally investigated. Given there is no difference between blood types and infection, I also wouldn't expect a difference. Blood type typically has little clinical significance outside of blood product transfusion compatibility, organ donation compatibility, and HDN - hemolytic disease of the newborn (Rh- mother has Rh+ fetus and fetal blood enters mother's circulation causing an immune response).
 

The problem with the single dosing plan is that there is insufficient research on how long this level of immunity is sustained longterm. It's nice to know that a single dose has 80% efficacy on day 14, but what about down the road. Without having solid evidence that the 80% can be sustained, I think it's risky decision to make, but I understand the ethical implications in terms of being able to vaccinate more people, faster. There is a reason Moderna decided to use a two dose course, I'm not entirely sure what evidence specifically lead them to that choice. I would assume there is some Phase I/II or pre-clinical data to support this decision.

I don't think it's wise to alter the dosing when we don't have the evidence to backup the decision. I definitely think it's something that should be investigated however (and is). Only looking at efficacy and antibody levels 2-4 weeks down the road though does not provide the information necessary to extrapolate into longterm efficacy.

Agree, but how is the LONG TERM immunizing ability of mRNA vs DNA ?

I know there hasn't been enough time to monitor presence of the anti spike proteins due to the emergency use authorization compared to conventional vaccine testing....

Do you expect we will need boosters or new vaccine shots every year or less ??

The J&J adenovirus DNA delivery design seems like it would last longer due to the stability of DNA vs RNA ???

Yes, no one knows for sure and we will have to monitor this. While mRNA vaccines are new to the market, they have been researched for quite some time. Both Moderna and Pfizer project 2-3 years of immunity, but of course there's no way to truly know for their respective vaccines until we can make those observations. Looking at some of the DNA vaccines on the market, they seem to last at least 10 years, but that doesn't mean that's what to expect with COVID as these existing products are for very different viruses.

DNA is the longterm storage format of genetic material. DNA creates mRNA, which is basically a temporary copy and therefore not as durable (m = messenger). The mRNA is then used as the template to create the viral spike protein, which the immune system then recognizes as bad and immunity is formed. Basically DNA and mRNA vaccines work the same, the DNA vaccines just start one step back by inserting the DNA into the host cell nucleus. Once the cell is manufacturing the viral proteins and the immune system recognizes these as foreign, it will mark the infected cell for destruction destroying everything, including the viral DNA, ending the ability for more proteins to be formed. So it's a little difficult for me to see why a DNA vaccine would somehow last much longer. Hopefully I explained that in a digestible manner.

I think it's possible we may have to get yearly vaccines. But if we have 95% efficacy, that may not be necessary. It may take several years and boosters to get there, but I am optimistic. The virus does not mutate particularly well, but up until now there has been virtually no natural pressures for the virus to mutate (ie immunity). So we'll have to see how new strains arise and how well the vaccines work against them.
 
The problem with the single dosing plan is that there is insufficient research on how long this level of immunity is sustained longterm. It's nice to know that a single dose has 80% efficacy on day 14, but what about down the road. Without having solid evidence that the 80% can be sustained, I think it's risky decision to make, but I understand the ethical implications in terms of being able to vaccinate more people, faster. There is a reason Moderna decided to use a two dose course, I'm not entirely sure what evidence specifically lead them to that choice. I would assume there is some Phase I/II or pre-clinical data to support this decision.

I don't think it's wise to alter the dosing when we don't have the evidence to backup the decision. I definitely think it's something that should be investigated however (and is). Only looking at efficacy and antibody levels 2-4 weeks down the road though does not provide the information necessary to extrapolate into longterm efficacy.



Yes, no one knows for sure and we will have to monitor this. While mRNA vaccines are new to the market, they have been researched for quite some time. Both Moderna and Pfizer project 2-3 years of immunity, but of course there's no way to truly know for their respective vaccines until we can make those observations. Looking at some of the DNA vaccines on the market, they seem to last at least 10 years, but that doesn't mean that's what to expect with COVID as these existing products are for very different viruses.

DNA is the longterm storage format of genetic material. DNA creates mRNA, which is basically a temporary copy and therefore not as durable (m = messenger). The mRNA is then used as the template to create the viral spike protein, which the immune system then recognizes as bad and immunity is formed. Basically DNA and mRNA vaccines work the same, the DNA vaccines just start one step back by inserting the DNA into the host cell nucleus. Once the cell is manufacturing the viral proteins and the immune system recognizes these as foreign, it will mark the infected cell for destruction destroying everything, including the viral DNA, ending the ability for more proteins to be formed. So it's a little difficult for me to see why a DNA vaccine would somehow last much longer. Hopefully I explained that in a digestible manner.

I think it's possible we may have to get yearly vaccines. But if we have 95% efficacy, that may not be necessary. It may take several years and boosters to get there, but I am optimistic. The virus does not mutate particularly well, but up until now there has been virtually no natural pressures for the virus to mutate (ie immunity). So we'll have to see how new strains arise and how well the vaccines work against them.
I’ve decided to get the 2nd dose. Planning on a long weekend. Getting it on the 26th.
 
I’ve decided to get the 2nd dose. Planning on a long weekend. Getting it on the 26th.
And just to point out, you’re not the only one that’s considered just getting only 1/2 of the vaccinations. I suspect others are in your position that sometimes can read too deep on the ‘internet files’ into the effects of the second dose where it can be over-bearing. Just focus on hydration, rest and you’ve got a game plan where you don’t have a ‘heavy work’ load that follows your 48 hour recovery.

Best.
 
And just to point out, you’re not the only one that’s considered just getting only 1/2 of the vaccinations. I suspect others are in your position that sometimes can read too deep on the ‘internet files’ into the effects of the second dose where it can be over-bearing. Just focus on hydration, rest and you’ve got a game plan where you don’t have a ‘heavy work’ load that follows your 48 hour recovery.

Best.
I chose Friday as I have the weekend off. I work in healthcare. So I’m well informed. Most of my hesitation is my huge phobia of injections. Not needles but the injection part.
 
I chose Friday as I have the weekend off. I work in healthcare. So I’m well informed. Most of my hesitation is my huge phobia of injections. Not needles but the injection part.
That’s interesting, I’ve never come across somebody that’s been concerned with the injection part, usually the sight of needles in general. But I think people are starting to figure out now with the recent side effects from dose 2, to give yourself at least two days off post injection, versus having the ‘I’ll work through it’ type of attitude. It’s just a safe bet.
 
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That’s interesting, I’ve never come across somebody that’s been concerned with the injection part, usually the sight of needles in general. But I think people are starting to figure out now with the recent side effects from dose 2, to give yourself at least two days off post injection, versus having the ‘I’ll work through it’ type of attitude. It’s just a safe bet.
Guess I’m weird. But the stick is nothing. When they push the plunger I feel like I may faint. Never have but I usually just sit down.
Blood draws dont bother me in the least. In fact I can and have drawn my own blood.
 
Guess I’m weird. But the stick is nothing. When they push the plunger I feel like I may faint. Never have but I usually just sit down.
Blood draws dont bother me in the least. In fact I can and have drawn my own blood.
I know this sounds kind of juvenile, but have thought about listening to music while they start the injection? By doing that, it’s more of a mental distraction that you can’t really hear what’s going on and you don’t get the prompt from the nurse like ‘Are you ready?’ I’m not saying that would work for everybody, but it might be a temporary remedy where you listen to one of your favorite songs that optimistically put you in a different vibe and overall cause that distraction within those 3-5 seconds.
 
I know this sounds kind of juvenile, but have thought about listening to music while they start the injection? By doing that, it’s more of a mental distraction that you can’t really hear what’s going on and you don’t get the prompt from the nurse like ‘Are you ready?’ I’m not saying that would work for everybody, but it might be a temporary remedy where you listen to one of your favorite songs that optimistically put you in a different vibe and overall cause that distraction within those 3-5 seconds.
Wouldn’t work for me. I know what they are doing. I feel the stick and know what’s coming. I’ve given many injections also so. I just ask to be seated and usually grab the side of the chair with my other hand and squeeze. Eyes are closed the entire time. Grimacing the whole time. Always get asked if I’m ok.
Always am. Lol

I get my shots when needed but don’t like it.
 
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