Ok, so I have a CanoScan LiDE80 and LiDE100. When I got CS4, and installed it, neither of those would show up under the File>Import menu. Normally they'd be there, you'd click them, and it launches the scangear app within photoshop. Basically they were MIA. I found a folder on the installation DVD called "Goodies" In there is a folder called Optional "Plug-Ins" In there is a folder called "Import-Export" What is the ONE file in that folder??? TWAIN.plugin Put that into Adobe Photoshop CS4/Plug-ins/Import-Export and you are golden. This should work for any TWAIN-based scanner. I can NOT believe Adobe didn't include this in the basic install of Photoshop, as it's been there at least since CS, probably since before that, and MOST scanners are still using TWAIN. I hope this helps someone!