Hello people and in advance, excuse my English. Well, to briefly describe myself, I'm a newcomer with OSX environment since my company bought me a MBP retina. I'm a hardcore gamer, have always been on Windows OS, and very sensitive to the tiniest lag.
So at a first glance, after the "wow, that's beautiful" effect (beautiful but not necessary more than its concurrent as shiny and rounded frames have fallen out of favor nowadays, but that's personal and far from the subject), I quickly realized how laggy this laptop is, when the world seems to say that Apple makes perfect products.
Like some of you, I don't understand why we are experiencing this. Ok, there are tons of pixels but, come on, some cheaper graphic cards run 3D games and our CPU is quite powerful so why some traditional 2D UI are causing all of that ? It's not only a Chrome's problem, most of the apps are not perfectly smooth unless we reduce them to fewer pixels. So it should definitely be software related.
Okay, all of that was just for saying. Now if some of you still have some lag issues with Chrome, I managed to make it run totally smooth (and when a gamer say totally smooth, that means above a hundred frames per second). Most of you may not need the whole process though.
First, stand with the default retina resolution (selecting above helps but it's so bad to underuse this absolutely splendid screen). Then make your Chrome browser take only the place it should. To do that, reduce its width to the smallest you can, then click the green "maximize" button to let it adapt as it wishes. This is both a trivial but very relevant advice. Now, go back to "chrome://flags" and enable "Override software rendering list", force "GPU compositing on all pages" as well as "Threaded compositing" (select enabled), also enable "GPU Accelerated SVG Filters" and "Disable GPU VSync" (it DOES make a huge difference). I also enabled "HTTP Pipelining, "Enable SPDY/3" and some other things but that doesn't concerns graphics so do as you want.
Now enable "FPS counter", restart Chrome and test this very page or some lightweight websites, that should be 100% smooth. Try Facebook, that's not perfect but incredibly easier on the eyes.
See you later now I tend to love my MacBook
Edit: I'm so sorry I just realized I upped a topic some months old, but that's still the first Google result when you wonder why your laptop is laggy so I assume it could still help.