My iPad is my main digital photo album, so I usually sync mine whenever I create a new album, which is usually a few times a month. About half the time, when I find an app I want, I will download it with iTunes on my laptop and then sync it to my iPad. All this is done wirelessly. I can't remember the last time I actually connected mine to my laptop.
The same goes for my daughters' minis though I tend to sync theirs wirelessly more often as they have music on theirs. They also like to take LOTS of photos and videos, so after we weed them and decide which ones they are keeping, I will connect theirs to my laptop to organize them.
My iPad backs up to iCloud whenever I charge it, though my kids' minis backup to my laptop whenever they are synced.