Do you just use whatever content blocker comes with Firefox?HTTPS Everywhere and Privacy Badger haven't caused me any problems, but I'm not sure that HTTPS Everywhere is even necessary now so I've disabled it to see if I can note a difference.
See: https://blog.mozilla.org/security/2...roduces-https-by-default-in-private-browsing/
I don't use Ublock Origin so I can't say.