A seasoned traveler like the the OP should have no problems navigating NYC.
The Guggenheim is great, but with the Met only a few blocks away, I would try to see both. Never been to the Natural History Museum, but it's just on the other side of Central Park. This group doesn't have quite the same compactness as the Museumkwartier in Amsterdam, but still convenient. The MoMA is on its own in Midtown, so that could be a tentpole for a different day.
Central Park is nice, and a bike rental facilitates seeing more of it than simply walking, in a very pleasant way (provided the climate is not too hot and muggy, but you've been to Asia, so that won't be a shock).
Most cities have their share of interesting and distinctive neighborhoods, so I'd try to do that research beforehand, according to one's interests.
In terms of typical tourist attractions, I'd prioritize the Statue of Liberty and Ellis Island over things like the Empire State Building and Times Square, which may be worth doing once, but in a more "been there, done that" way. But that's how I roll.
The Subway can take one to most places, and avoids the delays of surface traffic.
Above all, enjoy.
The Guggenheim is great, but with the Met only a few blocks away, I would try to see both. Never been to the Natural History Museum, but it's just on the other side of Central Park. This group doesn't have quite the same compactness as the Museumkwartier in Amsterdam, but still convenient. The MoMA is on its own in Midtown, so that could be a tentpole for a different day.
Central Park is nice, and a bike rental facilitates seeing more of it than simply walking, in a very pleasant way (provided the climate is not too hot and muggy, but you've been to Asia, so that won't be a shock).
Most cities have their share of interesting and distinctive neighborhoods, so I'd try to do that research beforehand, according to one's interests.
In terms of typical tourist attractions, I'd prioritize the Statue of Liberty and Ellis Island over things like the Empire State Building and Times Square, which may be worth doing once, but in a more "been there, done that" way. But that's how I roll.
The Subway can take one to most places, and avoids the delays of surface traffic.
Above all, enjoy.