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+1 I wear mine this way. I actually find it easier and more natural to use my thumb on the buttons and my index finger on the screen. It also avoids the problem of the crown being pressed if the Watch slips down, and I bend my wrist too far.

Exactly why this lefty wears his watch on his right wrist with the crown/button on the right side... thumb for crown/buttons, and finger for the screen.
 
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