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Yes, there seems to be different size SSDs on removable cards for the new Mini built to the Apple specs and only used on the Mac mini. Lots of luck sourcing them outside of the Apple garden. And what other tweaks might be necessary to the BIOS or other chips is an unknown for the new size to work.

Would those tweaks carry through a MacOS update/upgrade? And forget any warranty.

For me with a military discount, a Mac mini M4 Pro with 14-core CPU and 20-core GPU, 64GB of memory, 8TB SSD and 10Gb ethernet plus a nano screen Studio Display prices out at $6,479 with sales tax and annual Apple care.

This mini system with display could outperform my M1 Ultra Studio with 128GB of ram and 8TB SSD specs and cost less than the Mac Studio alone.

The bang for the buck is getting louder every year. My IIfx with a a 80 GB hard drive, 32 mb memory and a Radeon video card cost over $11,000 1990 dollars. Most every thing was on plug in boards with slots for memory. Other than the CPU, all else was changeable if one had the time and money. Note I did not include the 21" color monitor that needed nearly two guys to carry it. But I had the "works" with that system in it's day.

In four years or less, that M1 Ultra will seem like the first Intel 386 computers when comparing process progress.
 
Being able to take the drive out if the motherboard dies to save data is a must-have for professionals. I don't want a "pro" machine that is dangerous for my work.
Soldering stuff with the sole purpose of shortening lifespan and making upgrades cost 4 times market's average is just evil to me.

If you are using a computer for professional work you certainly have multiple backups
 
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I believe in the department of redundancy department. Multiple backups. Really important items are in the cloud and a remote structure on another property.

As a suggestion, have a backup computing device that can double check if the issue is the backup device if there is an access issue or the laptop or the interface cable.

In addition to my M4 Max MBPro laptop, there is an Ultra Mac Studio on my desk and a M2 Pro Mac mini file server in my office.

Also, check the operation of the backup device once in awhile to refresh the storage. The word is that those CD backups of yesteryear are getting long in the tooth and may not be readable.
 
I find it problematic that you are posting an article about an iFixit teardown without providing a single link to the iFixit website.
 
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