I ran into a situation where FF 3 crashed on OS X taking 90 minutes of online application with it. I installed chrome, spent roughly an hour resubmitting the application and haven't used FF since. Any software that robs me of my time has to go. The critical flaw occurred when I was offered a print preview of a pdf generated by the online site. I decided to save it off to read later and that's when FF went down the toilet.
Chrome is slightly faster, a lot clunkier but at least it hasn't crashed and taken my work with it. I was also having problems with FF sync. I'm now using xmarks as I couldn't get google to properly sync either. Xmarks works all day every day on every browser and platform I want it to so if I ever tire of Chrome, I can use xmarks to take my profile over to another browser.
I've used dreamweaver to make a few web sites. I used it to convert clunky font tags and so forth to css but I found it a lot cleaner to start from scratch and have to define fewer styles than the dozens dreamweaver would come up with if I let it. While I still have DW installed, more often than not, I'm sitting in a terminal window editing html, css and php in vi.
One problem I have with Safari is it isn't really cross platform. Windows and OSX are not the only choices these days. On Linux, I still use FF but on my iThings (iPhone, iPad) I'm forced to deal with Safari. It does screw things up from time to time but it's not all that bad. Still, when I have a choice I use Chrome or FF.