They're pin-compatible. People have been dropping quad core Xeons into Mac Pros for a while now. There's no reason they shouldn't be able to do the same with C2D and C2Qs.
edit: yay for my not adding anything to the conversation.
Just to note, "pin-compatible" doesn't always imply compatible. There are occasionally differences in power requirements and such that prevent the chips from working properly.
-Clive