Hmm, I am not convinced that it's connection of antena via the hand that's causing the issue. I just wrapped my hand in a plastic bag and held the phone - no skin on skin, and the issue still persisted. If you hold it in your left hand, there is more "hand" for the signal to go via...
It could just be the phone software is struggling to deal with a weaker signal, or a strong -> weak signal.
It could just be the phone software is struggling to deal with a weaker signal, or a strong -> weak signal.