Well, I have zero problems syncing my iPhone 4S running iOS 6.1b1 with iTunes 10.6.3 on my PowerMac G5, so I'm pretty sure you won't have any trouble with your 3GS either.
I have no problems syncing my iPhone or my Apple TV with iOS6 to iTunes from my G5 Xserve either. In fact my G5 will even do AirPlay mirroring from iTunes 10.6.8
First, yes I have read the whole thread.
Second, I wasn't rude to anyone, so don't be rude.
Third as said it is as different connector, although the same as the older shuffle.
If anyone can answer me I appreciate it.