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The phone can be a bit uncomfortable to hold if you're on the phone for quite a while. I experienced this when I first purchased my iPhone 4. However, if you put a case on the phone, you should feel a difference, especially if you talk on the phone for long periods of time.

Honestly, though, you shouldn't have to put a phone in a case just so it feels like it was designed with even the slightest nod towards ergonomics.
 
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