Guess what, Laurene also said "don't hold anything back, Steve has a lot of skeletons in his closet."
So it's not like she's upset that he was portrayed in any kind of negative light. Laurene and his team at Apple are upset about something else. The accuracy of his portrayal. Sure Isaacson could have all the access in the world, it doesn't matter to his conclusions or interpretation. It's like saying that data creates the conclusion in scientific research. Data only provides context, it doesn't provide the conclusion. It's up to the human interpreting the data to arrive at the conclusion.
Reading through Isaacsons biography, the guy simply didn't get it. Factual errors, or completely missing the mark on some of the most important and well known events of his career. If he can't even piece together important events like the purchase of NeXTStep and the subsequent development of Mac OSX, I'd be highly skeptical of the accuracy of his conclusions for much of the book.
Everyone on here making assumptions about Laurene and Tims motives are completely clueless. No one, except for Laurene and Steves friends, actually know their reasoning for disliking Isaacsons book. None of us actually know Steve Jobs as well. They do. It's ridiculous to accuse them of things when all of us don't have the slightest clue.