I found a solution for my setup: The mouse had a lot of short lacks like it would loose connection several times. Interestingly the problem never appeared with the keyboard. One thing I found out was, that problems increased when iPhone placed near the mouse with bluetooth activated. After not finding a solution I decided to un-connect the mouse from bluetooth and pair it with the logitech dongle. I placed the USB dongle on the arm of my desk light and so it is quite near above the mouse. Immediately the problems disappeared and never came back for almost 4 weeks now. Highly recommend doing this.
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