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My record is 34 days. I only restart / shutdown if updates are required. As of this morning it's been on for 18 hrs
 
I'm currently at 28 days and 5 hours. Guess that means I last rebooted around New Year's Eve. Going to see if I can get a year's worth of uptime, just for kicks.

Oh, and I'm running 10.4.11.
 
Mine only get rebooted for updates, and has been on for several days at a stretch without even sleep mode.

I've always treated my Macs this way (desktops and laptops) and have never had a problem.
 
Longest I have had it on is maybe a little under twenty four hours. I'll normally shut down my laptop when I am not using it.
 
I leave mine on all the time, but I do let it sleep when I'm not using it. The occasional reboot when Software Update asks for it and when things go nuts.

Current uptime is just over 9 days. Though it's been up for longer than that before.
 
Currently

Code:
tim-crosss-macbook:~ Tim$ uptime
22:42  up 4 days,  3:09, 2 users, load averages: 0.40 0.69 0.89
tim-crosss-macbook:~ Tim$

I had a KP a few days ago - had been up since the MWSF updates. I never turn it off by choice.
 
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