I don't yet have a Thunderbolt 3 enclosure to try unfortunately.
Do we think FileVault boot is a likely addition, that is not yet implemented?
Well, I don't think that matters to the enclosure.
It could matter to the storage media used.
And definitely it matters how the macOS deals with that.
In my OWC TB3 enclosures I have 4 SATA SSDs and 4 Seagate IronWolf NAS drives.
As SoftRAID 6 isn't ready yet, I use Disk Utility to create RAIDs, ScaryRAIDs that is.
Two Seagate IronWolf NAS drives in one RAID, the other similar RAID as backup.
ScaryRAID is aptly named because if one drive dies all data in that RAID is lost.
The four 2 TB SATA SSDs form a single 8 TB RAID.
On my older Intel Mac those were used in a RAID 5 configuration.
Such a wasteful use!!!
Completely unnecessary for scratch storage.
The performance hit for writes is simply not worth it.
Also, typically SSDs don't all of a sudden die.
If one keeps monitoring them most likely there will be advanced warnings.
So, as a TM backup and as an external boot drive I have two TB3 2TB SSDs.
The OWC Envoy Pro FX has a detachable cable.
On the EX the cable is solidly integrated and can't be detached.
I have not tried out encryption here either.