Just to update, I have the eGPU working under OSX 10.13.2. I'm not sure what changes were needed since too many permutations of cable/monitor/power up sequence were tried. I have a secondary monitor on the Mac Mini HDMI and the primary monitor on the eGPU Displayport. Boot screen shows up on the primary monitor. The secondary monitor does not need to be powered on for the system to boot or wake from sleep, but it appears that using the HDMI on the Mini was required when installing the High Sierra 10.13.2 update.