There is no benefit to leave it running.
Well, one obvious benefit is that you would stop being concerned about the position of the power button, and about the cooling when used upside down.
Add to it the time you would have saved by not writing this thread, and you have a clear win.
No need to mention the ability to carry out a number of tasks while in Power Nap, or the fact that you can access all of your files from any other device in your possession, such as your phone, iPad, laptop or Apple TV, using “wake for network access”.
Also let’s not talk about how one can schedule jobs overnight, that you don’t particularly want to run while you are using the Mac, such as CCC backups as I do on my Mac.
Apart from that, there is no benefit to leave it running.