I asked because Firefox is a bit more prominent on my system now, but, I can't find a smoking gun. e.g. Firefox core process only has around 330MB private memory, and it is the largest. There are lots of isolated content processes, most of them at 0% CPU. No one process has that much private memory. The processes with the most accumulated time over the last couple of days are the kernel, audiomxd, WindowServer, configd. I'm not sure why audiomxd is as high as it is.
Edit: And yet, memory pressure is constantly yellow, in the top half. Until recently, that was never the case for very long. And, the system is sluggish. That was never true either, no matter what I was doing.
Edit:16 hours after rebooting, and restarting all the apps that were running, including multiple web browsers with many tabs, photos, presumably looking for people and pets, and everything is still perfectly normal. No mysterious unattributable memory pressure, perfectly responsive to the keyboard and to mouse clicks to different apps. Just like the old days. If this follows the pattern, in a day or two the system will get sluggish, memory pressure will appear basically out of nowhere, with no visible guilty app, and, it will be time to reboot again.