Yes. You could put the operating system, data, and software on the hybrid drive and then use the 1 TB as a backup in the SuperDrive bay, enclosure, or your router. It is not a good idea to have that be your only backup though because if the machine gets destroyed or lost then your backup goes with the machine defeating the purpose.
So along with the 2 hard drive had a separate external drive that is a backup as well?
Regards!