You definitely have to get used to it, especially if you have the adjustable base. For example, I'm used to sleeping on my side, which is hard to do if the bed isn't flat. The flexed positions are much more conducive to sleeping on my back, and I'm still getting used to that.
I didn't get the adjustable base, just the platform with a C2 mattress. On the up-side, it will be REAL easy to move out of my place should I decide to move. The way the doors are set up, things that don't bend become a challenge to get in and out.