For starters it will finally abandon the architecture that began with the Pentium Pro back in 1995 and therefore be based on a whole new architecture.
It will have an integrated memory controller that uses the Intel QuickPath interconnect, which replaces the good old Front Side Bus and have 1 to 8+ cores on a single package. It will be based on 45nm as the current Penryn and some versions will even come with integrated graphic on the same processor package.
The server version will use the LGA1366 socket with support for registered DDR3.