Seems to me we just have to wait for the drivers (and ROM) with the Mac Q4000 and then see how far we get adapting it for GTX 480 etc.
There could be superficial and easily removed obstructions such as PCI ID linking, slightly deeper stuff like counting the cores or working only on the number in the Q4000, through to weird obstructions on some GTX but not others.
Right now I do not think any of us know how more widely useful the final Q4000 drivers will be, but I AM sure we will know within days of them hitting the web. All we really know is that the transient premature release a few weeks ago allowed us to inject 480s but only to run at a fraction of full speed (and so far no OS X CUDA either). If we get a 480 up that is no guarantee that a 460 will work, judging by the trouble people had with GTX 275s. I know this is a rumor site but until we get another driver we are stuck in pure speculation, IMHO.