I use it all the time, to the point where I am disappointed that not all apps support the gestures for links. I try to peek at a link in Twitter just to bring up the share sheet. I use a 6S+, and I could see where on a 6S the problem of your hand getting in the way of the content could be a larger deal, but you can move your finger horizontally after pressing to get it out of the way, which is useful.
how does it work on tweetbot?I find myself using the 3D Touch more now that more 3rd party apps utilize it.
Best I've found so far are Instagram and Tweetbot.