I've been using Safari for a while, but I'm almost ready to switch to Chrome. First of all, Safari truly is a resource hog - when I have lots of tabs open at the same time for a while, it will take up to 700 (!!) MB of RAM, while Chrome will only take up about 350-400 MB with the same amount of open tabs.
Second, there is rarely any beachballing in Chrome when I open several tabs at the same time or when pages load. Page loading is just smoother than in Safari, because the latter tends to beachball/freeze for a sec or two. And the fact that Chrome treats each tab separately is also quite great.
Third, Chrome's "Awesome bar" is just so much easier to utilize in searching for both the websites you've visited before or other websites that you perhaps know a part of the name of, but not the entire address - the bar will help you find it easily because it's basically a Google search at the same time. Safari is crap when it comes to this.
Moreover, I like how you can hide Chrome's "Status bar" and still get your status displayed in the "pop-up" type of Status bar that Chrome provides. In Safari it's either have the status bar, or not have it at all.
To the OP: why don't you get Glims for Safari? One of the numerous customizations it offers is the option to open links in new tabs as opposed to new windows, which you find annoying.
What I still don't like about Chrome is:
- can't remove the bloated "Other bookmarks" folder in the Bookmarks bar, which is just ridiculous - people have been demanding it for quite some time, yet Google still haven't done jack about it!!
- the gap between Bookmarks bar favicons is a bit too wide, I wish it could be possible to cram it a bit closer so to gain some extra space
- no tab customization
- how to bring back websites that you might have lost by accidentally closing the browser?
- no "Stop" button?
- no bookmark separators