Eh. I used Chrome for about a week on my Windows machine at work. Tried to like it. Tried real hard, but just couldn't. My biggest thing (outside of the annoying bugs) is I hate that hideous blue UI. I just can't get past it. I'll try the Mac version when it comes out, but I'm not all that hopeful.
I prefer Safari on my Macbook, but FF closed the gap a bit (for me) with 3.5. It's very smooth and really improved in the rendering font dept - and it's plenty fast. I'm using it as much as I ever have.