I’m not a fan of Apple’s options and pricing for drives. But that isn’t a problem with Fusion Drives. That is Apple marketing choices.
"Apple’s options and pricing for drives" is the
only reason why we're still talking about Fusion drives.
Looking on Amazon, there's a
2TB WD M.2. SSD stick for $330 - now its only a SATA drive, so its not the same speed as Apple's PCIe parts, but it will most likely out-perform a
Fusion drive by a long chalk - without the added complexity. Plenty of PCs (including All In Ones, laptops and SFFs) can take one or two M.2 sticks. The only point of a Fusion drive now is because the only pure SSD alternative Apple are offering is a super-fast super-expensive proprietary PCIe drive.
If you've got a few-years-old Fusion drive machine that you're happy with, fine - but IMHO anybody buying a new, high-end machine today should really look beyond having spinning rust built in to their all-in-one or SFF computer... and for those of us that want to stick with MacOS that means paying Apple prices.
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Well, if you definitely want a 5k display, iMac (Pro or regular) is a no-brainer, since it includes more-or-less the same screen as the $1300 LG. Economically, the mac mini only makes sense if you're going to "bring your own display and keyboard". If I were getting a Mini I'd pair it with a more affordable "4k" UHD display and an existing - or third party - keyboard & mouse. (Personally, I can't bear the Apple mouse and the Magic Keyboard II is nothing to write home about for the price).
The big issue for you is going to be the GPU performance - we'll probably have to wait for benchmarks but I can't see the Intel integrated graphics in the Mac Mini holding a candle to the discrete graphics in the iMac/iMac Pro. CPU I wouldn't want to call - the Mini might beat the iMP in a single-threaded sprint, so it probably depends on your exact workflow and how much advantage it takes of the extra 2 cores in the iMP (and how much the Mac mini throttles).
The other question is whether the Mini's ram is going to be
officially user upgradeable (I know its in sockets - but how much glue will you need to fight past to get at them and will it void the warranty?) - if it is, you'll probably save money by upgrading it yourself.
Seems to me that the "sweet spot" for the Mini is the $1099 configuration (esp. if you can cheaply upgrade the RAM). Beyond that, the prices get silly for integrated graphics (and eGPUs are currently silly expensive).