Ultimately, it will depend on the capacity of any upgrades, new applications you decide you want,... and the frequency by which you add them.Thanks.
Just wondering about capacity. The total of my Library, System and Applications is about 120GB. For the Intel X25-M the largest capacity is 160GB - presumably this would be enough? I doubt I'll be adding new applications other than upgrades.
All 4 hard drive bays are filled - but I will have plenty of space on one drive to use as a scratch disk.
How much space does the boot drive (eg. the SSD) need for things like 'page outs' (which usually is low, I have 8GB RAM and it's plenty for my use).
You don't want to completely fill an SSD, as it needs unused capacity (~10 - 20%, the more the better) for wear leveling. Intel's do have some unused capacity (10% = bare min.) that's invisible to the user, but it's a good idea to leave a little more IMO. Other makes may not, so be aware of it and check. But no matter the brand you get, DON'T fill it all the way.
There are larger capacity drives out there (I'm not sure which is the best though), so do the research if the 160GB Intel's not quite large enough.
Another option could be to add in another unit later for additional applications. You can even RAID them together (you could run into throttling issues if you run an SSD set at the same time as mechancial drives/RAID sets), so a hardware RAID card may be in order. It will depend on the details at the time you decide that this may be an acceptable option.