I go back and forth between pressing the home button on my iPad and swiping up on my iPhone X, which I've had since December. I am so relieved that iOS 12 brings the iPhone X gestures to my iPad!
After 10 months of swiping up on one device, and pressing a home button on the other, I prefer swiping up by a big margin.
I also much prefer FaceID to TouchID. My only concern about removing the home button is accessibility. Some people, including my 82 year old mother, find the home button to be reassuring in its simplicity. She has an iPhone 8+ that she loves, because it works just like her old iPhone 6+ did. I'm sure she would get the hang of swiping after a brief period of frustration, but the home button is what allows even the least tech-savvy among us to pick up an iPhone and just start using it.
It's not tiring at all, but it is VERY annoying, I wish there was a setting to turn this off. One of the few things I miss from Android is proximity lock, and also Bluetooth lock, where the device would remain unlocked without security if it was in a location, on a wifi/Bluetooth network, etc.
It’s kind of funny when you think about it. Human beings have gone from having to fight and struggle for food and shelter, many not even surviving to adulthood, to “does swiping your finger on a phone cause fatigue?”