I took this quote to heart a month ago, sold most of my Canon DSLR gear (still have a 50 1.4 & 50 1.8 Mk 1 to sell) and bought a X100. Best decision ever.
It's small and light enough to carry with me everywhere, the IQ is still fantastic, I can firmly carry it in positions that would require me to gain 5 pounds of arm muscle to do the same with 5D/24-105 combo. Just love it.