Does it not require iTunes in a similar fashion?
I'm not sure I follow this discussion well.
I replaced my 2013 MacBook Air (8MB RAM/512GB SSD) for a 12.9-inch iPad Pro (Wi-Fi+Cellular/128GB storage) about two months ago now. Prior to truly making that switch, I was slowly shifting to using my iPad Air 2 (Cellular/128GB storage) as my daily driver for about six months but still on a Mac maybe 20%-40% of the time. My primary apps are Microsoft Office, Do.com, Safari, Mail and Messages.
My primary file storage provider is mixed between Google Drive (business) and Dropbox (personal), along with shared space on other services for specific client projects (Microsoft Sharepoint, Microsoft OneDrive and Box being the most common, in that order). Because of the split-screen functionality, all this works great on my iPad Pro. I also often have the Comcast Xfinity X1 TV app running in a window while working with news or sports playing.
Part of making this transition work is
not using the iPad in the same manner I would have used my Mac ten years ago by relying on local files on a hard drive. Instead, it's primarily meant to work via cloud services. And, largely, it works really well.
I do keep offline copies on my iPad for all current work-in-progress, just in case I find myself wanting to work without some type of Internet access. However, outside of trans-Atlanic flights, that doesn't seem to happen very much anymore. When I recently bought a 60GB data SIM while staying in rural Portugal for 30 Euros to be able to do HD videoconferencing with clients from whatever village I found myself in, my iPad-centric life hit an inflection point of never looking back. I'm sitting in a cafe in Lithuania right now using a 5GB for 0.58 Euro/day prepaid data SIM! "How many days will you be here? That'll be 8 Euros total."
I'm not sure why one absolutely needs iTunes on a Mac or PC for an iPad? I do listen to music, watch movies and read books on my iPads and iPhone, but most often it's with Spotify, Infuse and Kindle. Apple also made the transition from "iTunes on a Mac" to "iTunes from the cloud" rather seamless for my old library of music files because of iTunes Match. For that reason, I haven't synced an iPhone or iPad to iTunes via a USB cable or iTunes Wi-Fi sync in almost five years.
I can see a day in the future when I turn off iTunes Match and just have copies of songs available via Dropbox or maybe DS audio, the iOS Synology music app. My Synology NAS seemed much more relevant pre-iPad-centricity than it does now, I don't think I'll be buying a replacement when mine dies. I don't really access it anymore, it's just hooked up to my cloud file server accounts so it has a local copy of everything sitting in in my home in Chicago.
I will admit every now and then I do hook up an iPhone or iPad to iTunes to just have a complete encrypted backup when I transition to newer devices rather than purely relying on iCloud backups. I'm not sure it's really needed, but I still do it.