I have one city out of the three in the region that is a total disaster. Its on high ground and half the city is split by a ridgeline making a percentage of the area unusable.
This is the city that has all of the regions oil, ore and coal, and has the least amount of water. I'm constantly chasing the clean water table with pumping stations and despite the other two cities having an overabundance of clean water, meters pegged in the green, and selling to this other city, it never has enough water and crucial services keep closing due to lack of water.
Plus, I had to chase the ore, coal and oil as it gets removed from an area and springs up in another. So I'm always tearing down large swaths of the city and rebuilding it.
Then there was a meltdown at the power plant and a good percentage of the city is unusable due to radiation.
Despite all of this, its still making money by means of trading, but I have a hard time getting metal and oil to the great works site.
What bothers me the most is chasing the water nonstop.
The other two cities are doing very well.