I have a GTX 780Ti (non EFI) in my mid 2012 6 Core 5.1. It runs off 1x6 pin and 1x8 pin directly off the motherboard. My PCI-e slots are filled by a GT120 for boot screen purposes, a USB 3 and esata port card and the last slot is taken up by a 4 port Firewire 800 card. No drama whatsoever. I don't understand the need to grab more power from the optical drive bay etc and to my knowledge the 780Ti is far more power hungry than the Titan.
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