I’m a lefty too and found almost every case with a cutout uncomfortable. Seems to be a thing…Could be the difference between being right or left-handed. I hold my phone in my left hand and really struggle with cases that have a cutout. My right-handed wife has no concerns as the cutout side of the case is always just up against her palm. FWIW, I find the Paragon a bit uncomfortable to hold because I’m left-handed, but I have no issues using the camera control button through the cutout. I guess I’m right in the middle lol