In my understanding that's not something new. WRT cMP, 100% compatibility OS support for any current GPU architecture is not to be expected at all by any means, but where there is a will there is always a way. So far I find RX 480 to be mainstream all rounder card capable of being compatible with all cMP in aspects of power efficiency, native drivers, and cost/performance. Anyhow, what kind of specific issues lead you to the thought?
You are right on! The reference designs are usually conservatively build for wide range of systems with compatibility in mind. But if one of the aftermarkets works well with certain level of compatibility as the reference does, isn't it a great news for cMP owners? It may be well worth of a few extra dollars in exchange for better performance, reduced noise level, dual BIOS switch, and light (bonus). e.g.
Sapphire Nitro+ RX 480 8G features ~10% boost over reference, quiet under load, V BIOS switch for custom overclock in Mac and Window, elegant design with RGB lighting, and most importantly its safe power draw at peak <225W (Even if more, MP's 1x mini 6 pin can handle up to ~120W?). I just ordered it in order to experience myself.
There are evidence RX460 works with native support (not official tho)... just plug 'n play on MP r? Or What do you really mean?