It's no coincidence that the iPad is 4:3 and the iPad accounts for more than 84 percent of all tablet web traffic.iPad is designed around being used in portrait (placement of home button, logo and camera).
Android 16:10 tablets are designed around being used in landscape (stereo speakers, camera, logos, etc).
I think it depends on what you get used to FIRST or how well you're able to change your style of usage.
Also your usage depends on what you prefer. If all you do is movies and even games you might prefer 16:10. If you browse the web and read pdf's mostly or whatever you may prefer 4:3.
The 4:3 aspect ratio is preferable for virtually every possible handheld activity besides TV/movies.