As a graphic designer, I used to always buy the pro towers. Powermac G4, Powermac G5. And that was mainly for longevity reasons. With the PCI slots, I was able to upgrade and add USB ports and swap out video cards.
However, with the Mac Pro, Apple released a machine with more power than someone like me needs. The price premium didn't really justify the longevity claim.
Secondly, with Intel's multi-core processors, mobile computing has gotten a lot more powerful. I currently use an iMac and a MBP for my design work. And both are sufficient for my needs. The drawback is that I can't really add cards and upgrade the machines outside of upping the RAM.
I agree - the future is multi-core. And the iMac is perfect for a mid-range pro machine these days.