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I'd never have a belt holster. Out of the question, just not my style or comfort!
Personally, I've always found them convenient, and there are models (the sideways-saddle type) that look more discreet than others, especially when worn under a shirt or jacket.
However, this is not the case with the 6s plus -- that huge holster makes you look like a federal agent.
 
Came from a 6plus to 6s plus, and have no regrets at all i will never ever go back to the smaller iPhone for nothing in the world...
 
I went from a 5S to the 6S+ and there was definitely an adjustment period, but a week later and it's practically second nature. I have pretty long fingers so the screen size is not much of an issue for one-handed use for me. Actually had to turn off Reachability because it was more of a nuisance than anything else :p
 
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