If the iPhone 6s+ had the glass back the iPhone 4 had, I wouldn' t have a case. The reason I have a case is to slightly help when it falls, but mainly to avoid slipping it out of my hands. I can't hold it without dropping it without a case, I use it while walking, biking, etc. I'd kill it within a month probably.
BUT, I honestly hate cases, well, that's strong. I really prefer no case. And I like simplistic design and feel, and look, i have the leather case, because it's thing, nicely designed, and feels great in the hand. It also keeps that professional look and doesn't turn it into some neon glowing big plastic laptop looking device. If i wanted an ugly phone i'd go with an old samsung or something.
If it was up to me i'd get a professional and custom wrap for it, but I switch out for a Moment lense once in a while, so i rather have the case come off rather easily. And it's just easier to clean this way.
I don't use screen protection, and i almost never drop the phone (mainly because the case prevents the slipping) and I am sure i will one day regret that, but since my first iPhone it's been good.
Anyway.. not a big case person.