If one is dropping that kind of dough and wants performance why skimp on it, go for the gt3.The main thing you want to be aware of is that the 4GB card runs much hotter than the 2GB which means 2 potential issues;
1. Fan noise(well documented in the M295X)
2. Long term effects of high thermal temps in the iMac. No your iMac won't melt but be cautious of any issues down the road. Don't listen to anyone who blindly says 'Apple engineers these computers for high temps'. Use your own head and make your own decision. BMW engineers the M3 for high performance as well, doesn't mean it's going to have the same reliability as a 328.