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Hi Yes there is* - My Mac Pro 5,1 2010 running 10.12.6. I just installed a Sapphire RX 580 Nitro+ 4GB version. No Boot screen. Login screen works as normal. Is recognised as "AMD R9 xxx 4096 MB" Metal is Supported, All resolutions over DP work on my 27" Dell Screen. Lux Bench Score 13794 - Geekbench 4 OpenCL test 132695. Blows the original 5770 away. System Profile can't display PCI tab as says error gathering information. Am going to download and test 10.13 beta soon. All 36 GPU units are recognised but no idea if the PCIE bus is running at 2.5 or full 5G link speed. **Just tested High Sierra Beta and can confirm that the card is being used at half speed 2.5 Link Speed.
 
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Yes.

I bought a Red Dragon (who on EARTH comes up with these stupid names?) 8 GB 580 yesterday and it worked perfectly in my 4,1. No need to download drivers, etc.

Performance seems in line with cost (I paid $225 at Microcenter including tax).

Only question I have is if I should order a twin 6 pin to 8 pin cable - right now I'm running it with a single 6 pin to 8 pin.
 
It would be helpful to have a twin 6 pin to 8 pin. That way you can supply the right power needed.
 
Hi Yes there is* - My Mac Pro 5,1 2010 running 10.12.6. I just installed a Sapphire RX 580 Nitro+ 4GB version. No Boot screen. Login screen works as normal. Is recognised as "AMD R9 xxx 4096 MB" Metal is Supported, All resolutions over DP work on my 27" Dell Screen. Lux Bench Score 13794 - Geekbench 4 OpenCL test 132695. Blows the original 5770 away. System Profile can't display PCI tab as says error gathering information. Am going to download and test 10.13 beta soon. All 36 GPU units are recognised but no idea if the PCIE bus is running at 2.5 or full 5G link speed. **Just tested High Sierra Beta and can confirm that the card is being used at half speed 2.5 Link Speed.

Yes, I've the exact same issue with the 8gb Sapphire version, the PCI info isn't there, only the error gathering info message. The card works perfectly otherwise under 10.12.6 running a LG Ultra hd display. Do you think this is just an issue that can be ignored? I can't upgrade to High Sierra yet. May I ask how long have you been running the card for? assuming you've had no other issues?

I've put in my old 7970 card until I have more info.
 
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