Hi Yes there is* - My Mac Pro 5,1 2010 running 10.12.6. I just installed a Sapphire RX 580 Nitro+ 4GB version. No Boot screen. Login screen works as normal. Is recognised as "AMD R9 xxx 4096 MB" Metal is Supported, All resolutions over DP work on my 27" Dell Screen. Lux Bench Score 13794 - Geekbench 4 OpenCL test 132695. Blows the original 5770 away. System Profile can't display PCI tab as says error gathering information. Am going to download and test 10.13 beta soon. All 36 GPU units are recognised but no idea if the PCIE bus is running at 2.5 or full 5G link speed. **Just tested High Sierra Beta and can confirm that the card is being used at half speed 2.5 Link Speed.