There is a point where a company can decide the regulatory framework imposed by the state is just too restrictive, and leaves.
We see it all the time in the US, when a company leaves one state for a “business-friendly” state.
I don’t think we’re close to this with Apple and the EU, but if the EU fines Apple for their App Store then fines them for things like FaceTime or iMessage being closed, or the phones not being user friendly, or some other reason… and it becomes tens of billions of euros or more, Apple may just throw up their hands and say “we’re done here”.