Kinda wierd comparison, the A53 is a much larger phone.
Spec wise the A53 beats the Se hands down, so unless you absolutely want a smaller phone the A53 wins there.
OS is imho simular and depends on personal preference.
Support is on par, samsung getting 5 years, SE probably longer (but with the smaller battery will require investing in a new battery a few years in).
Price: A53 1/5th ceaper then the SE
Spec wise the A53 beats the Se hands down, so unless you absolutely want a smaller phone the A53 wins there.
OS is imho simular and depends on personal preference.
Support is on par, samsung getting 5 years, SE probably longer (but with the smaller battery will require investing in a new battery a few years in).
Price: A53 1/5th ceaper then the SE