You’re throwing around meaningless words of a bygone era. You need to explain why SoC architecture, fast SSD drives and large super fast caches for processing (on the chip!) can’t solve your problem?
A problem you fail to understand in the first place! There’s no such thing as low memory anymore. It’s the job of macOS to fill RAM to the max, no matter how much you have and make memory available if needed. That’s why Activity Monitor has a chart for Memory Pressure not Memory Usage.
Anyway, even if memory pressure on your system is high, the data is loaded from a fast SSD, not a spinning drive with a mechanical read-write head. This bottleneck has been eliminated. It’s a thing of the past like the Gigahertz race.
This is silly. If your working set is bigger than what fits in RAM, you need more RAM. SoC architecture, fast SSD drives, and fast caches can’t solve that. There are numerous examples of such working sets, including the ones he listed, as well as engineering and science applications. No matter how fast your SSD drive is, if you have to randomly access a data set that is bigger than RAM, each read will be at least two orders of magnitude slower than if it fits in RAM.
And as a guy who’s Ph.D dissertation had “memory hierarchies” in its title, I’ve spent a year or 25 thinking about this issue.