I have two calibrated displays attached to my Mac Mini, and every time that I restart the Mac, my display color profiles revert from the calibrated profiles to the defaults. I then have to go into the display settings and reselect the latest calibrated profile for each display...which sticks until I restart the Mac again. UGH. I've never had this problem in all of my years as a Mac owner. What's going on? I am on Sierra 10.12.1, using a Late 2014 Mac Mini. One display is an Asus ProArt, the other is an LG, both are calibrated with an X-Rite i1 Display Pro. Super ninja kudos to anyone who can figure this out. Thanks!