We'll have to wait and see, really. VPC and VMware both do some emulation, which will increase security and decrease speed. Depending on how they are written, they may or may not be able to use graphics acceleration.
WINE would be lowest security, but should be the fastest, since it just runs the app with minimal remaping. (Really, it is the same idea as Carbon on Cocoa...) Which should mean that it is fast and allows full access to the system (or at the same access as any other program).
But in the end, all of these will be optimized as much as the programmers can. If VPC is well optimized, it may well be faster than a poorly optimized WINE, and have more support. It's just up to what level of programming support they each have.
Likely WINE will (eventually) not support everything, but will support enough to run most applications. Graphics card support would probably depend on how the app is calling the card: OpenGL would just be passed through, but DirectX would need emulation/translation. A custom driver, and all bets are off.
There is one difference that might come into play though: VMware and VPC would require you to actually have a copy of Windows to run in the emulator. WINE wouldn't. 😉