Hi Marse
I didn't update any BIOS or anything else before this.
I actually just now finished installing Windows 10 Pro Build 1909, directly on my Mac Pro 4.1(5.1) with bootcamp drivers and all, via a Win 10 DVD drive, In my first attempts something was wrong with the downloaded ISO/DVD I had burned, and it said "Missing drivers...." I took and created a new ISO from another more recent Windows 10 Pro machine with the mediacreationtool. and the Installation worked out of the box just by booting into the DVD with holding "c" at boot time. Also worth mentioning is all was done with the RX 580 in the Machine, and all other Disks taken out to not make any mistakes on partitions. i did this test on a 60 Gb disk, and will redo this again on a larger SSD to make it more permanent.
The only downside I have noticed is that the BootCamp Application on windows can't recognise Mac APFS drives so the Bootcamp switching between the two OS'es does not work properly, only from the Mac side it works, if booted into Windows 10, I can't get back to MacOS if selected on the Windows side, and have to do a CMD+alt+R+P to get the Mac to boot back into High Sierra.
Other than that it seems to work very well with my Sapphire Radeon RX 580.
Thanks
Michael